Our lab investigates noncoding RNA “dark matter” in stem cells and cancer. There are tens of thousands of uncharacterized noncoding RNAs in our genome, many of which are misregulated in cancer. We use genomic and genome engineering technologies to discover and understand the functions of noncoding RNAs in pluripotent stem cells and cancer formation. In particular, our laboratory investigates how oncogenic RAS signaling regulates the noncoding transcriptome during the initial stages of cellular transformation. We are also developing RNA-based liquid biopsy approaches to enable highly sensitive and specific early detection of RAS-driven cancers using genomic approaches.